Nonlinear static and dynamic analysis of mixed cable elements

This paper presents a family of finite elements for the nonlinear static and dynamic analysis of cables based on a mixed variational formulation in curvilinear coordinates and finite deformations. This formulation identifies stress measures, in the form of axial forces, and conjugate deformation measures for the nonlinear catenary problem. The continuity requirements lead to two distinct implementations: one with a continuous axial force distribution and one with a discontinuous. Two examples from the literature on nonlinear cable analysis are used to validate the proposed formulation for St VenantKirchhoff elastic materials. These studies show that displacements and axial forces are captured with high accuracy for both the static and the dynamic case

The synthesis of monomers with pendent ethynyl group for modified high performance thermoplastics

The objectives of this project were to develop synthetic schemes for the following classes of modified monomers: (1) difunctional triarylethanes with pendent acetylenic groups; and (2) tertiary aspartimides with terminal acetylene groups at the two ends. Our efforts have resulted in the successful development of high yield schemes for the syntheses of several diamino and bisphenolic analogs of difunctional triarylethanes with pendent ethynyl group. A scheme for one new tertiary aspartimide was also established. Multi-gram samples of all prepared new monomers were provided to our technical contact at NASA-LaRC and preliminary polymerization studies were encouraging. Details of the accomplished work within the last four years are described

Two-Twistor Space, Commuting Composite Minkowski Coordinates and Particle Dynamics

We employ the modification of the basic Penrose formula in twistor theory, which allows to introduce commuting composite space-time coordinates. It appears that in the course of such modification the internal symmetry SU(2) of two-twistor system is broken to U(1). We consider the symplectic form on two-twistor space, permitting to interpret its 16 real components as a phase-space. After a suitable change of variables such a two-twistor phase space is split into three mutually commuting parts, describing respectively the standard relativistic phase space (8 degrees of freedom), the spin sector (6 degrees of freedom) and the canonical pair angle-charge describing the electric charge sector (2 degrees of freedom). We obtain a geometric framework providing a twistor-inspired 18-dimensional extended relativistic phase space $\mathcal{M}^{18}$. In such a space we propose the action only with first class constraints, describing the relativistic particle characterized by mass, spin and electric charge.Comment: LaTeX 2e, 14 pages. To be published in the Proceedings of XIX-th Max Born Symposium "Fundamental Interactions and Twistor-Like Methods", September 2004, American Institute of Physics, Proceedings Serie

Aldosterone upregulates transient receptor potential melastatin 7 (TRPM7)

Transient receptor potential melastatin 7 (TRPM7) is a ubiquitously expressed Mg2+-permeable ion channel fused to a C-terminal α-kinase domain. Recently, aldosterone was shown to increase intracellular Mg2+ levels and alter inflammatory signaling in TRPM7-expressing HEK293 cells. This study was undertaken to assess whether these effects were related to an aldosterone-mediated increase of TRPM7 current and/or plasma membrane localization. Using HEK293 cells stably expressing WT-TRPM7, we found that 18-h application of aldosterone significantly increased TRPM7 current and TRPM7 plasma membrane protein expression by 48% and 34%, respectively. The aldosterone-mediated increase of TRPM7 current was inhibited by eplerenone, a mineralocorticoid receptor (MR) blocker, and GSK-650394, an inhibitor of the serum- and glucocorticoid-regulated kinase 1 (SGK1). SGK1 blockade also prevented the aldosterone-induced increase of TRPM7 plasma membrane protein. It was further determined that K1648R-TRPM7, the phosphotransferase-inactive TRPM7 mutant, was unresponsive to aldosterone. Therefore, chronic aldosterone treatment increases the plasma membrane expression of TRPM7, which is associated with an increase of TRPM7 current. This process occurs via an MR-dependent, genomic signaling cascade involving SGK1 and a functioning TRPM7 α-kinase domain. We suggest that this mechanism may be of general relevance when interpreting the effects of aldosterone because the MR receptor is found in multiple tissues, and TRPM7 and SGK1 are ubiquitously expressed

Helminth species richness in wild wood mice, Apodemus sylvaticus, is enhanced by the presence of the intestinal nematode Heligmosomoides polygyrus

We analysed 3 independently collected datasets of fully censused helminth burdens in wood mice, Apodemus sylvaticus, testing the a priori hypothesis of Behnke et al. (2005) that the presence of the intestinal nematode Heligmosomoides polygyrus predisposes wood mice to carrying other species of helminths. In Portugal, mice carrying H. polygyrus showed a higher prevalence of other helminths but the magnitude of the effect was seasonal. In Egham, mice with H. polygyrus showed a higher prevalence of other helminth species, not confounded by other factors. In Malham Tarn, mice carrying H. polygyrus were more likely to be infected with other species, but only among older mice. Allowing for other factors, heavy residual H. polygyrus infections carried more species of other helminths in both the Portugal and Egham data; species richness in Malham was too low to conduct a similar analysis, but as H. polygyrus worm burdens increased, so the prevalence of other helminths also increased. Our results support those of Behnke et al. (2005), providing firm evidence that at the level of species richness a highly predictable element of co-infections in wood mice has now been defined: infection with H. polygyrus has detectable consequences for the susceptibility of wood mice to other intestinal helminth species

Quantum computation with phase drift errors

We present results of numerical simulations of the evolution of an ion trap quantum computer made out of 18 ions which are subject to a sequence of nearly 15000 laser pulses in order to find the prime factors of N=15. We analyze the effect of random and systematic phase drift errors arising from inaccuracies in the laser pulses which induce over (under) rotation of the quantum state. Simple analytic estimates of the tolerance for the quality of driving pulses are presented. We examine the use of watchdog stabilization to partially correct phase drift errors concluding that, in the regime investigated, it is rather inefficient.Comment: 5 pages, RevTex, 2 figure

A quantum gate array can be programmed to evaluate the expectation value of any operator

A programmable gate array is a circuit whose action is controlled by input data. In this letter we describe a special--purpose quantum circuit that can be programmed to evaluate the expectation value of any operator $O$ acting on a space of states of $N$ dimensions. The circuit has a program register whose state $|\Psi(O)>_P$ encodes the operator $O$ whose expectation value is to be evaluated. The method requires knowledge of the expansion of $O$ in a basis of the space of operators. We discuss some applications of this circuit and its relation to known instances of quantum state tomography.Comment: 4 pages, 3 figures include